产品详情
Isotype（亚型） | IgG |
Calculated MW（分子量） | 理论分子量41kDa/42kDa；实际分子量40kDa |
Immunogen（免疫原） | Recombinant protein (or fragment). |
Gene ID | 1432/6300/5600 |
Swiss Prot | |
Purification Method（纯化方式） | Affinity purification |
Subcellular location（亚细胞定位） | Cytoplasm, Nucleus, cytoplasm, cytosol, extracellular region, glutamatergic synapse, mitochondrion, nuclear speck, nucleoplasm, nucleus, spindle pole. |
Applications（应用）
Species reactivity（反应种属）
Human Mouse Rat Monkey
Tested Applications（已测试应用）
WB IHC-P IF/ICC ELISA
Recommended Dilutions（推荐稀释比例）
Tested Applications | Recommended Dilutions |
WB | 1:2000 - 1:10000 |
IHC-P | 1:150-1:600 |
IF/ICC | 1:50-1:100 |
ELISA | Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. |
Storage（储存）
Storage Buffer（储存缓冲液）
PBS with 0.09% sodium azide,0.05%BSA,50% glycerol,pH7.3.
Storage Instruction（储存条件）
Shiped at 4℃.Short term 4℃(1-2weeks).It isrecommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Background Information（背景信息）
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
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