服务介绍
Isotype（亚型） | IgG |
Calculated MW（分子量） | 理论分子量41kDa；实际分子量38kDa |
Immunogen（免疫原） | Recombinant protein (or fragment). |
Gene ID | 1432 |
Swiss Prot | Q16539 |
Purification Method（纯化方式） | Affinity purification |
Subcellular location（亚细胞定位） | Cytoplasm, Nucleus, cytoplasm, cytosol, extracellular region, glutamatergic synapse, mitochondrion, nuclear speck, nucleoplasm, nucleus, spindle pole. |
Applications（应用）
Species reactivity（反应种属）
Human Mouse Rat
Tested Applications（已测试应用）
WB IF/ICC ELISA
Recommended Dilutions（推荐稀释比例）
Tested Applications | Recommended Dilutions |
WB | 7000 - 1:25000 |
IF/ICC | 1:100 - 1:200 |
ELISA | Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. |
Storage（储存）
Storage Buffer（储存缓冲液）
PBS with 0.09% sodium azide,0.05%BSA,50% glycerol,pH7.3.
Storage Instruction（储存条件）
Shiped at 4℃.Short term 4℃(1-2weeks).It isrecommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Background Information（背景信息）
This gene encodes a member of the MAP kinase family. MAP kinases integrate multiple biochemical signals and participate in various cellular processes including proliferation, differentiation, transcriptional regulation and development. This kinase is activated by diverse environmental stresses and proinflammatory cytokines. Its activation depends on phosphorylation by MAP kinase kinases (MKKs), or autophosphorylation induced by binding to MAP3K7IP1/TAB1. Its substrates cover transcription regulators ATF2, MEF2C and MAX, cell cycle protein CDC25B, and tumor suppressor p53, indicating its functions in stress-associated transcription, cell cycle control and genotoxic stress response. Four alternatively spliced transcript variants encoding different isoforms have been identified.
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