服务介绍
Isotype（亚型） | IgG |
Calculated MW（分子量） | 理论分子量289kDa；实际分子量289kDa |
Immunogen（免疫原） | Recombinant protein (or fragment). |
Gene ID | 2475 |
Swiss Prot | P42345 |
Purification Method（纯化方式） | Affinity purification |
Subcellular location（亚细胞定位） | Cytoplasm, Cytoplasmic side, Endoplasmic reticulum membrane, Golgi apparatus membrane, Lysosome, Mitochondrion outer membrane, Nucleus, PML body, Peripheral membrane protein. |
Applications（应用）
Species reactivity（反应种属）
Human Mouse Rat
Tested Applications（已测试应用）
WB ELISA
Recommended Dilutions（推荐稀释比例）
Tested Applications | Recommended Dilutions |
WB | 1:500-1:2000 |
ELISA | Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. |
Storage（储存）
Storage Buffer（储存缓冲液）
PBS with 0.09% sodium azide,0.05%BSA,50% glycerol,pH7.3.
Storage Instruction（储存条件）
Shiped at 4℃.Short term 4℃(1-2weeks).It isrecommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Background Information（背景信息）
This gene encodes a phosphatidylinositol kinase-related kinase. Kinases within this family mediate cellular responses to stresses including DNA damage and nutrient shortage. This kinase forms two separate complexes: mTORC1 governs protein synthesis, cell growth and proliferation, while mTORC2 modulates the actin cytoskeleton and supports cell survival and cell cycle progression. It serves as the target through which the FKBP12-rapamycin complex induces cell-cycle arrest and immunosuppression. mTOR inhibitors are applied as immunosuppressants in organ transplantation and are under investigation for SARS-CoV-2 treatment. Gene variants are linked to Smith-Kingsmore syndrome and somatic focal cortical dysplasia type II. The ANGPTL7 gene resides within one of its introns.
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