服务介绍
Isotype（亚型） | IgG |
Calculated MW（分子量） | 理论分子量289kDa；实际分子量289kDa |
Immunogen（免疫原） | Recombinant protein (or fragment). |
Gene ID | 2475 |
Swiss Prot | P42345 |
Purification Method（纯化方式） | Affinity purification |
Subcellular location（亚细胞定位） | Cytoplasm, Cytoplasmic side, Endoplasmic reticulum membrane, Golgi apparatus membrane, Lysosome, Mitochondrion outer membrane, Nucleus, PML body, Peripheral membrane protein, Phagosome, Microsome membrane, Lysosome membrane. |
Applications（应用）
Species reactivity（反应种属）
Human Mouse Rat
Tested Applications（已测试应用）
WB IF/ICC ELISA
Recommended Dilutions（推荐稀释比例）
Tested Applications | Recommended Dilutions |
WB | 1:1000 - 1:5000 |
IF/ICC | 1:50 - 1:200 |
ELISA | Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. For high-ratio antibody dilutions (≥1:10000),a sequential dilution method is strongly recommended to ensure measurement accuracy. |
Storage（储存）
Storage Buffer（储存缓冲液）
PBS with 0.09% sodium azide,0.05%BSA,50% glycerol,pH7.3.
Storage Instruction（储存条件）
Shiped at 4℃.Short term 4℃(1-2weeks).It isrecommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Background Information（背景信息）
This gene encodes a phosphatidylinositol kinase-related kinase. Its family members mediate cellular responses to stresses such as DNA damage and nutrient deprivation. The kinase functions in two distinct complexes: mTORC1 controls protein synthesis, cell growth and proliferation, while mTORC2 regulates the actin cytoskeleton and supports cell survival and cell cycle progression. It serves as the target of the FKBP12-rapamycin complex, which induces cell cycle arrest and immunosuppression. mTOR inhibitors are used as immunosuppressants for organ transplantation and under evaluation for SARS-CoV-2 treatment. Gene variants are associated with Smith-Kingsmore syndrome and somatic focal cortical dysplasia type II. The ANGPTL7 gene resides in one of its introns.
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