服务介绍
Isotype（亚型） | IgG |
Calculated MW（分子量） | 理论分子量47kDa；实际分子量54kDa |
Immunogen（免疫原） | Recombinant protein (or fragment). |
Gene ID | 5728 |
Swiss Prot | P60484 |
Purification Method（纯化方式） | Affinity purification |
Subcellular location（亚细胞定位） | Apical plasma membrane, Cell projection, Cytoplasm, Cytoplasmic side of plasma membrane, Cytosol, Dendritic spine, Extracellular region, Myelin sheath adaxonal region, Neuron projection, Nucleoplasm, Nucleus, plasma membrane, PML body, Postsynaptic density. |
Applications（应用）
Species reactivity（反应种属）
Human Mouse Rat
Tested Applications（已测试应用）
WB IHC-P IF-P ELISA
Recommended Dilutions（推荐稀释比例）
Tested Applications | Recommended Dilutions |
WB | 1:1000-1:2000 |
IHC-P | 1:50-1:200 |
IF-P | 1:50-1:200 |
ELISA | Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. |
Storage（储存）
Storage Buffer（储存缓冲液）
PBS with 0.09% sodium azide,0.05%BSA,50% glycerol,pH7.3.
Storage Instruction（储存条件）
Shiped at 4℃.Short term 4℃(1-2weeks).It isrecommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Background Information（背景信息）
This gene encodes PTEN, a frequently mutated tumor suppressor. PTEN functions as phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, containing a tensin-like domain and a dual-specificity phosphatase domain. Unlike most tyrosine phosphatases, it preferentially targets phosphoinositides and suppresses the PI3K/AKT pathway by reducing cellular PIP3 levels. A non-canonical upstream CUG initiation codon generates a longer isoform associated with the mitochondrial inner membrane to modulate mitochondrial energy metabolism. A PTEN pseudogene resides on chromosome 9. Alternative splicing and multiple translation start sites produce several transcript variants encoding distinct isoforms.
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